Thirteen people have died in a crash between a fuel tanker and minibus taxi on the R33/R614, near Wartburg in the KwaZulu-Natal Midlands on Tuesday morning.
KwaZulu-Natal Emergency Medical Services spokesperson Robert McKenzie said paramedics treated five people on the scene for critical injuries.
He said the cause of the collision was unknown. In total, four vehicles were involved in the crash, it later emerged.
The spillage of petrol and diesel led to a total road closure, McKenzie said.
Transport Minister Fikile Mbalula has expressed sadness, following the crash.
"We are horrified by this collision. The gruesome nature of this crash and the subsequent loss of life are devastating. We send our sincere condolences to those who have lost their loved ones in this incident and wish the injured a swift and full recover," Mbalula said.